This difference can typically be between 1 to about 70 microvolts per degree Celsius for the modern range of available metal combinations. Certain combinations have become popular as industry standards, driven by cost, availability, convenience, melting point, chemical properties, stability, and output.
Thermocouples are most suitable for measuring over a large temperature range, up to 1800 K. They are less suitable for applications where smaller temperature differences need to be measured with high accuracy, for example the range 0--100 °C with 0.1 °C accuracy. For such applications, thermistors and RTDs are more suitable.